Peran Riwayat Ayah Diabetes Melitus Tipe 2 pada Status Prediabetes Anak Kandung Penderita Diabetes Melitus Tipe 2

Maulidia Ekaputri, Henrico Citrawijaya, Kevin Jonathan Adhimulia, Adrian Reynaldo Sudirman, Radityo Ali Murti, Ayu Putri Balqis Sarena, Dyah Purnamasari

Abstract

Pendahuluan. Pasien diabetes melitus tipe 2 (DMT2) pada umumnya memiliki satu atau lebih komplikasi kronik pada saat terdiagnosis. Deteksi dini dan pencegahan sangat penting untuk mengurangi angka mortalitas dan morbiditas terkait DMT2, terutama pada kelompok dengan risiko tinggi seperti anak penderita DMT2. Studi ini bertujuan untuk mencari faktor-faktor yang berkaitan dengan status prediabetes pada anak dari penderita diabetes melitus tipe 2.

Metode. Studi ini merupakan studi potong lintang yang melibatkan 54 anak dari penderita DMT2. Subjek dikumpulkan secara konsekutif. Status prediabetes ditentukan melalui HbA1C berstandar national glycohemoglobin standardization program (NGSP). Aktivitas fisik ditentukan melalui kuisioner global physical activity questionnaire (GPAQ)-versi Bahasa Indonesia. Tekanan darah dan data antropometrik diukur secara langsung. Analisis bivariat dan multivariat dilakukan dengan IBM SPSS 23.

Hasil. Dilakukan analisis terhadap 54 subjek. Mayoritas subjek adalah perempuan (79,6%) dan rerata umur adalah 38,8 tahun. Proporsi prediabetes mencapai 31,5%. Analisis multiavariat menunjukkan hubungan bermakna antara riwayat paternal DMT2 (adjusted OR 7,520; IK 95%=1,071-52,784), lingkar pinggang berisiko (adjusted OR 5,482; IK 95%=1,019-29,504) terhadap status prediabetes.

Simpulan. Riwayat paternal DMT2 dan lingkar pinggang berkaitan dengan status prediabetes pada anak dari penderita DMT2.

Kata Kunci: Anak penderita DM tipe 2, HbA1C, intoleransi glukosa, prediabetes

 

The Role of Paternal History of Type 2 Diabetes Mellitus on Prediabetes Status among The Offspring of Type 2 Diabetes Mellitus Patients

 

Introduction. Since patients with type 2 diabetes mellitus (T2DM) often present with one or more chronic complications, at the time of diagnosis, early detection and prevention is essential to reduce T2DM-associated mortality and morbidity, espescially among high risk population such as the offspring of T2DM. This study aimed to investigate several factors associated with prediabetes status among the offsprings of T2DM patients.

Methods. A cross-sectional study was conducted involving 54 offsprings of T2DM patients. Subjects were recruited consecutively. We collected demographic data, anthropometric measurement, blood pressure, and HbA1c level. Physical activity were assessed by using Indonesian version of global physical activity questionnaire (GPAQ). Prediabetes status was investigated by standardized national glycohemoglobin standardization program (NGSP) HbA1c. Bivariate statistical and multivariate analysis was performed by using IBM SPSS 23.

Results: The majority of subjects were female (79.6%) and the mean age was 38.8 years old. The proportion of prediabetes was 31.5%. Multivariate analysis showed significant association among paternal history of T2DM (adjusted OR 7.520; 95%CI=1.071-52.784), waist circumference at risk (adjusted OR 5.482; 95%CI=1.019-29.504), and prediabetes status.

Conclusion: Paternal history of T2DM and waist circumference were associated with prediabetes status among the offspring of T2DM patients.

Keywords

Glycated Hemoglobin, Glucose Intolerance, Offspring of T2DM, Prediabetes, Type 2 Diabetes Mellitus (T2DM)

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