Korelasi antara Kadar Transforming Growth Factor Beta (TGF- β) Serum dan Skor Beck Depression Inventory (BDI) pada Pasien Kanker Kolorektal di RSMH Palembang

Abstract

Pendahuluan. Depresi selain meningkatkan angka kematian, dapat juga menganggu kualitas hidup pasien kanker kolorektal selama perawatan. Inflamasi sistemik dalam kadar yang rendah dapat berkontribusi terhadap perkembangan terjadinya depresi. Proses inflamasi dapat dilihat dengan mengukur kadar transforming growth factor-β (TGF-β) serum dan gejala depresi menggunakan skor beck depression inventory (BDI). Penelitian ini dilakukan untuk mengetahui korelasi kadar TGF-β serum dengan depresi pada pasien kanker kolorektal.

Metode. Penelitian observasional analitik dengan desain potong lintang dilakukan pada pasien kanker kolorektal yang menjalani kemoterapi dengan skor BDI ≥10 di RSMH Palembang sejak Juni 2018 sampai dengan Juni 2019. Kadar TGF-β serum diukur dengan metode kuantitatif enzyme-linked immunosorbent assay (ELISA). Analisis Spearman digunakan untuk menilai korelasi kadar TGF-β dan skor BDI

Hasil. Dari 40 subjek didapatkan rerata TGF-β serum 108,14 pg/mL (simpang baku [SB] 39,97 pg/mL), dan   median  skor beck depression inventory (BDI) 14(10-28). Terdapat korelasi positif dengan kekuatan sedang antara kadar TGF-β serum dan skor BDI (r=0,485; p=0,002).

Simpulan. Terdapat korelasi positif dengan kekuatan korelasi sedang antara kadar TGF-β serum dan skor BDI pada pasien kanker kolorektal yang menjalani kemoterapi di RSMH Palembang.

Kata Kunci: Depresi, kanker kolorektal, skor BDI, TGF-β

The Correlation between Transforming Growth Factor-Beta (TGF- β) Serum Level and Beck Depression Inventory (BDI) Score in Colorectal Cancer Patients at RSMH Palembang

Introduction.Depression not only increase the mortality rate, but also can interfere the quality of life of colorectal cancer patients during treatment. Low levels of systemic inflammation may contribute to the development of depression. The inflammatory process can be seen by measuring serum transforming growth factor-β (TGF-β) levels and depressive symptoms using the beck depression inventory (BDI) score. This study aimed to determine the correlation between TGF-β serum levels with depression in colorectal cancer patients.

Methods. Analytical observational research with cross sectional design was conducted among colorectal cancer patients who underwent chemotherapy with a BDI score ≥10 (depression)in the RSMH Palembang from June 2018 to June 2019. Serum TGF-β levels were measured by the enzyme-linked immunosorbent assay (ELISA) quantitative method. Spearman analysis was used to assess the correlation of TGF-β levels and BDI score.

Results. A total of 40 subjects were included in this study with mean value of TGF-β serum was 108.14pg/mL(SD 39.97pg/mL). Medianbeck depression inventory (BDI) score was14 (range 10-28).  There was a moderate positive correlation between serum TGF-β levels and BDI score (r = 0.485; p = 0.002).

Conclusion. There was a moderate positive correlation between serum TGF-β levels and BDI scorein colorectal cancer patients at RSMH Palembang.