Uji Validitas dan Reliabilitas European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast 23 pada Pasien Kanker Payudara dalam Terapi

Mizanul Adli, Hamzah Shatri, Noorwati Sutandyo, Suhendro Suwarto

Abstract

Pendahuluan. Peningkatan angka ketahanan hidup pasien kanker payudara tidak selalu diikuti oleh peningkatan kualitas hidup. European Organization for Research and Treatment of Cancer (EORTC) menekankan pentingnya melakukan penilaian kualitas hidup pada pasien kanker. Saat ini, di Indonesia, belum ada kuesioner yang valid dan reliabel untuk menilai kualitas hidup pasien kanker payudara secara akurat. Penelitian ini bertujuan untuk membuktikan bahwa European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast 23 (EORTC QLQ-BR23) merupakan alat ukur yang reliabel dan valid digunakan di Indonesia

Metode. Penelitian ini adalah studi potong lintang. Penelitian dimulai dengan menerjemahkan EORTC QLQ-BR23 ke dalam bahasa Indonesia dan kemudian di uji coba pada 10 responden. Setelah itu, EORTC QLQ-BR23 hasil terjemahan digunakan pada penelitian utama dengan jumlah sampel yang lebih besar. Test-retest dinilai dengan Intraclass Correlation Coeficient (ICC). Konsistensi internal dinilai dengan cronbach alpha. Construct validity dinilai dengan multi-trait scaling analysis. Validitas kriteria dinilai dengan melihat korelasi antara domain European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Cancer30 (EORTC QLQ-C30) dan EORTC QLQ-BR23 dengan Short Form 36(SF36).

Hasil. Telah dilakukan pengambilan data terhadap 100 pasien kanker payudara yang menjalani terapi dari September - Oktober 2015. Nilai ICC (interval 1 jam) pada semua domain EORTC QLQ-BR23 sangat baik (ICC > 0,8). Terdapat penurunan nilai ICC (interval 30 hari) pada semua domain EORTC QLQ-BR23. Nilai cronbach alpha > 0,7 pada hampir semua domain EORTC QLQ-BR23 kecuali domain gejala lengan (Cronbach Alpha: 0,643). Multi-trait scaling analysis menunjukkan korelasi cukup tinggi antara skor butir pertanyaan dengan skor domainnya sendiri. Sedangkan hubungan butir pertanyaan dengan domain yang berbeda selalu mempunyai korelasi yang lebih rendah dibandingkan dengan domainnya sendiri. Pada uji validitas kriteria, didapatkan 19 korelasi dengan r > 0,3 antara domain EORTC QLQ-C30 dan EORTC QLQ-BR23 dengan SF36.

Simpulan. EORTC QLQ-BR23 merupakan alat ukur yang valid dan reliabel  untuk menilai kualitas hidup pasien kanker payudara di Indonesia

 

Kata Kunci: Kualitas Hidup, EORTC QLQ-BR23, Validitas, Reliabilitas, Kanker Payudara

 

Validity and Reability Test of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast23 in Breast Cancer Patient on Treatment

Introduction. Improved survival of breast cancer patients are not necessarily followed by improvement of quality of life. European Organization for Research and Treatment of Cancer (EORTC) emphasize the importance of assessing the quality of life in cancer patients. Currently, in Indonesia, there has been no reliable and valid questionnaire to assess quality of life of breast cancer patients accurately. This study aims to prove that the EORTC QLQ-BR23 is valid and reliable measuring instrument used in Indonesia.

Methods. This is a cross-sectional study. The study began with the EORTC QLQBR23 translated into Indonesian and then tested on 10 respondents. After that, The Indonesian version of EORTC QLQ-BR23 is used in the main study with a larger sample size. Test-retest was assessed with intraclass correlation coefficient (ICC). Internal consistency was assessed by Cronbach alpha. Construct validity was assessed by multi-trait scaling analysis. The criteria validity assessed by looking at the correlation between domains European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Cancer 30 (EORTC QLQC30) and EORTC QLQ-BR23 with Short Form 36 (SF36).

Results. Data collection were done on 100 breast cancer patients on treatment from September to October 2015. ICC value (1 hour interval) in all domains of EORTC QLQ-BR23 is very good (ICC> 0.8). There is a decline in the value of ICC (30 days interval) in all domains of EORTC QLQ-BR23. Cronbach alpha values > 0.7 in almost all domains of EORTC QLQ-BR23 domain unless symptoms arm domain (Cronbach's Alpha: 0.643). Multi-trait scaling analysis showed a fairly high correlation between the scores of the questions with a score of his own domain. While the relationship of the questions with different domains always have a lower correlation than the domain itself. In criteria validity test, obtained 19 correlation with r > 0,3 between domains EORTC QLQ-C30 and EORTC QLQ-BR23 with SF36.

Conclusion. EORTC QLQ-BR23 is a valid and reliable instrument for assessing quality of life of breast cancer patients in Indonesia

Keywords

Breast Cancer, EORTC QLQ-BR23, Quality of Life, Reliability, Validity

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